Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2(Cys6&Cys12 bridge , Cys7&Cys14 bridge)
Size : 1
P1(RMB) : 2758
MW : 3561.2
One letter sequence : Glp-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2(C6&C12 bridge , C7&C14 bridge)
Molecular Formula : C152H243N47044S4
Description : Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.
Literature Reference : M.W. Schwartz, Nature Med., 4, 385 (1998); T. Sakurai et al., Cell, 92, 573 (1998)
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