Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
Size : 0.5
P1(RMB) : 552
MW : 2460.9
One letter sequence : ARLDVASEFRKKWNKWALSR-NH2
Molecular Formula : C112H178N36O27
Description : Precursor of adrenomedullin containing proadrenomedullin NH2-terminal 20 peptide (PAMP), a unique 20-residue sequence. When administered, PAMP produces a strong and rapid hypotensive effect in anesthetized rats. PAMP has also been suggested to function as an inhibitory modulator of renal noradrenergic neurotransmission, thereby playing an important role in the regulation of renal functions. PAMP has been proposed to serve as an inhibitory regulator in adrenal catecholamine release in vivo and possesses a potent hyperglycemic effect after intra-third cerebroventricular administration in fasted mice.
Literature Reference : K. Kitamura et al., BBRC, 194, 720 (1993)
Cas : [150238-87-2]
