Size : 1
P1(RMB) : 153
MW : 611.61
One letter sequence : Ac-WEHD-CHO
Molecular Formula : C28H33N7O9
Description : Very potent reversible inhibitor of caspase-1 (ICE) that contains the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM, it displays the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
Literature Reference : T.A. Rano et al., Chem. Biol., 4, 149 (1997); M. Garcia-Calvo et al., J. Bio. Chem., 273, 32608 (1998)
Cas : [189275-71-6]
