Size : 1
P1(RMB) : 123
MW : 502.5
One letter sequence : Ac-DEVD-CHO
Molecular Formula : C20H30N4O11
Description : Potent inhibitor for the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC50=0.2 nM). PARP cleavage occurs at the onset of apoptosis. This peptide aldehyde is useful in attenuating apoptotic events in vitro (IC50 = 10 nM).
Literature Reference : D. Wissing et al., Proc. Natl. Acad. Sci. USA, 94, 5973 (1997)
Cas : [184179-08-6]
