Size : 1
P1(RMB) : 153
MW : 767.8
One letter sequence : Z-DEVD-AMC
Molecular Formula : C36H41N5O14
Description : AMC (7-amino-4-methylcoumarin) derived caspase substrates are widely used for the fluorimetric detection of various caspase activities. Cleavage of AMC peptides by caspases generates strongly fluorescent AMC that is monitored fluorimetrically at 440-460 nm with excitation of 340-350 nm. Caspase-3 and caspase-7 substrates
Literature Reference : Koeplinger KA, et al. (2000). Protein Expr Purif 18, 378-87;
Garcia-Calvo M, et al. (1998). J Biol Chem 273, 32608-13;
Thornberry NA, et al. (1997). J Biol Chem 272, 17907-11;
Rano TA, et al. (1997). Chem Biol 4, 149-55;
Margolin N, et al. (1997). J Biol Chem 272, 7223-8;
Mizushima N, et al. (1996). FEBS Lett 395, 267-71;
Faubion WA, et al. (1999). J Clin Invest 103, 137-45.
Cas :
