Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Size : 0.5
P1(RMB) : 460
MW : 1981.3
One letter sequence : GWTLNSAGYLLGPPPALALA-NH2
Molecular Formula : C94H145N23O24
Description : Antagonist of galanin receptor that significantly antagonizes galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. It inhibits the binding of (125I-Tyr26)-galanin (porcine) in rat hypothalamic membranes with IC50 value of 15nM.
Literature Reference : S.F. Leibowitz et al., Brain Res., 599, 148 (1992);
J.N. Crawley et al., Brain Res., 600, 268 (1993);
X. J. Xu et al., Br. J. Pharmacol., 116, 2076 (1995)
Cas :
