Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Size : 0.5
P1(RMB) : 582
MW : 2898.39
One letter sequence : RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
Molecular Formula : C123H212N44O35S1
Description : Hypothalamic neuropeptide that regulates feeding behavior and significantly augments food intake in a dose-dependent manner when a bolus is administered intracerebroventricularly. After a 48-hour fast, hypothalamic prpro-orexin mRNA level is up-regulated 2.4. The discovery of orexins and their receptors may provide a novel molecular basis for understanding the role of the lateral hypothalamic areas in the regulation of energy homeostasis.
Literature Reference : M.W. Schwartz, Nature Med<$>., 4, 385 (1998);
T. Sakurai et al., Cell, 92, 573 (1998)
Cas :
