Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
Size : 1
P1(RMB) : 1011
MW : 2687.3
One letter sequence : MAPRGFSCLLLLTSEIDLPVKRRA
Molecular Formula : C119H204N34O32S2
Description : Novel polypeptide that suppresses neuronal cell death induced by several familial Alzheimer's disease genes and by amyloid beta-protein (human). The secretion of amyloid beta-protein (1-40) and amyloid beta protein (1-42) has been shown not to be affected by humanin in F11 cells expressing the familial Alzheimer's disease gene K595N/M596L-APP. Inhibitory actions on neuronal cell death triggered by K595N/M596L-APP directly and caused by amyloid beta-protein have been suggested.
Literature Reference : Y. Hashimoto et al., Proc. Natl. Acad. Sci. USA , 98, 6336 (2001); Y. Hashimoto et al., Biochem. Biophys. Res. Commun., 283, 460 (2001)
Cas : [330936-69-1]
