Phe-Leu-His-Gln-Glu-Arg-Met-Asp-Val-Cys-Glu-Thr-His-Leu-His-Trp-His-Thr-Val-Ala-Lys
Size : 0.5
P1(RMB) : 321
MW : 2618
One letter sequence : FLHQERMDVCETHLHWHTVAK
Molecular Formula : C116H173N35O31S2
Description : This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid beta/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer's disease.
Literature Reference : G.Multhaup et al., Science, 271, 1406 (1996)
Cas : 315229-44-8
