Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val
Trifluoroacetate salt
Size : 1
P1(RMB) : 2320
MW : 3260.65
One letter sequence : EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV
Molecular Formula : C141H235N39O49
Description : This peptide was isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. It is the fragment (61-95) of NACP or alpha-synuclein and forms amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
Literature Reference : H.Han et al., Chemistry and Biology, 2, 163 (1995)
A.Iwai et al., Biochemistry, 34, 10139 (1995
Cas : 154040-19-4
