Ala-Thr-Lys-Ala-Ala-Cit-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Gly-Lys(Biotin)
Size : 0.25
P1(RMB) : 430
MW : 2975.5
One letter sequence : ATKAA-Cit-KSAPATGGVKKPHRYRPGGG-K(Biotin)
Molecular Formula :
Description : This peptide is the fragment of Histone H3 (21-44) with deimination at Arg26, converting it to Cit (citrulline). It is biotinylated through a C-terminal GGK linker. Deimination by peptidyl arginine deiminase 4 (PADI4) blocks methylation by the CARM1 methyltransferase and inhibits transcriptional activation.
Literature Reference : Cuthbert, G. et al. Cell 118, 545 (2004).
Cas : N/A
