H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH
Size : 0.5
P1(RMB) : 1210
MW : 2629.08
One letter sequence : AYC(Acm)RDGKIGPPKLDIRKEEKQI
Molecular Formula : C115H194N34O34S
Description : This peptide derived from the ligand binding site of the human gamma-interferon (IFN-gamma) receptor is an antagonist of human IFN-gamma. It inhibited human IFN-gamma-induced expression of HLR/DR antigen on Colo 205 cells with an approximate IC50 of 35 µM. Immobilized peptide specifically bound recombinant human IFN-gamma. Tyrosine substitution at residue 121 allowed facile quantification and conjugation of the peptide.
Literature Reference : G.F.Seelig et al., J. Biol. Chem., 270, 9241 (1995)
Cas : 158040-83-6
