Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Trifluoroacetate salt
Size : 5
P1(RMB) : 1040
MW : 1646.87
One letter sequence : Ac-SYS-Nle-EHfRWGKPV-NH2
Molecular Formula : C78H111N21O19
Description : Afamelanotide, a synthetic analog of alpha-MSH which shows prolonged biological activity and is 26 times more active than alpha-MSH in the adenylate cyclase assay.
Literature Reference : T.K.Sawyer et al., Proc. Natl. Acad. Sci. USA, 77, 5754 (1980)M.E.Hadley et al., Science, 213, 1025 (1981)K.R.Gehlsen et al., Pigment Cell Res., 5, 219 (1992)S.O.Ugwu et al., Biopharm. Drug Dispos., 18, 259 (1997)R.T.Dorr et al., Arch. Dermatol., 140, 827 (2004)M.E.Hadley and R.T.Dorr, Peptides, 27, 921 (2006)
Cas : 75921-69-6
