Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu
Trifluoroacetate salt
Size : 1
P1(RMB) : 3760
MW : 2584.05
One letter sequence : WYKHVASPRYHTVGRAAGLLMGL
Molecular Formula : C119H183N35O28S
Description : This peptide is an endogenous ligand of the G-protein-coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricular administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release.
Literature Reference : .Shimomura et al., J. Biol. Chem., 277, 35826 (2002)
S.Brezillon et al., J. Biol. Chem., 278, 776 (2003)
H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003)
M.S.Mondal et al., Endocrinology, 144, 4729 (2003)
Cas : 383415-79-0
