Size : 5
P1(RMB) : 314
MW : 666.78
One letter sequence : GYPGKF-NH2
Molecular Formula : C33H46N8O7
Description : Protease-activated receptor-4 activating peptide derived from murine PAR-4. This peptide was able to cause rat platelet aggregation with an EC50 value of 40 µM. Its effect on leucocyte rolling and adherence points at a role of PAR-4 in mediating proinflammatory processes.
The family of at least seven transmembrane G protein coupled receptors includes at least four receptor subtypes (PAR1, PAR2, PAR3, PAR4). PAR4 activating peptides, GYPGKF-NH2 and AYPGKG-NH2, produce concentration dependent contractile effects on the muscle.
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Cas : 245443-52-1
