Biotin-Lys-Gly-Trp-His-Leu-Lys-Ser-Lys-Lys(Ac)-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2
Size : 0.25
P1(RMB) : 529
MW : 3610.2
One letter sequence : Biotin-KGWHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2
Molecular Formula :
Description : This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
Literature Reference : Kubbutat, M. et al. Lett Nature 387, 299 (1997)
Li, M. et al. J Biol Chem 277, 50607 (2002).
Cas :
