Biotin-C6-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys(Ac)-Leu-Met-Phe-Lys-Thr-Glu-Gly-Pro-Asp-Ser-Asp-NH2
Size : 0.25
P1(RMB) : 636
MW : 4034.7
One letter sequence : Biotin-C6-GSRAHSSHLKSKKGQSTSRHK-K(Ac)-LMFKTEGPDSD-NH2
Molecular Formula :
Description : This is an amidated peptide derived from residues 361-393 of human p53 tumor suppressor protein with acetylation at Lys382. This peptide is biotin-labeled at its N-terminus with a 6-carbon LC linker. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
Literature Reference : Kubbutat, M. et al. Lett Nature 387, 299 (1997)
Li, M. et al. J Biol Chem 277, 50607 (2002).
Cas :
