Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-Gly-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-DLys-DLeu-DAla-DLys-DLeu-DAla-DLys-NH2 (S-S bonded C1-C4 & C2-C3)
Size : 1
P1(RMB) : 1410
MW : 2707.4
One letter sequence : ACDCRGDCFC-GG-klaklakklaklak-NH2 (S-S bonded C1-C4 & C2-C3)
Molecular Formula :
Description : This sequence is a targeted proapoptotic peptide. The C-terminal RGD-4C peptide (ACDCRGDCFC) binds preferentially to integrins at sites of tumor angiogenesis. Two glycines provide spacer, and D(KLAKLAK)2 is the proapoptotic peptide composed of D-amino acids.
Literature Reference : Lahdenranta, J. et al. FASEB J. 10.1096/fj.07-8273com (2007); Ellerby, H. et al. Nat. Med. 5, 1032 (1999); Smolarczyk, R. et al. Acta Biochim. Pol. 53, 801 (2006); Curnis, F. et al. Cancer Res. 64, 565 (2004); Su, Z. et al. Bioconjug. Chem. 13, 561 (2002).
Cas :
