Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2 (Disulfide bridge: 1-16, 8-20, and 15-25)
Size : 1
P1(RMB) : 2530
MW : 2639.1
One letter sequence : CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge: 1-16, 8-20, and 15-25)
Molecular Formula : C102H172N36O32S7
Description : Reversible N-type Ca2+ Channel Blocker
W-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitve Ca2+ channels in neurons. It has been used to identify different Ca2+ channel subtypes in amphibian brain.
Literature Reference : Olivera, BM. et al. Biochem. 26, 2086 (1987); Hillyard, DR. et al. Neuron. 9, 69 (1992).
B.M. Olivera, L.J. Cruz, V. de Santos, G.W. Le Cheminant, D. Griffin, R. Zeikus, J.M. McIntosh, R. Galyean, J. Varga,
W.R. Gray, and J. Rivier, Biochemistry, 26, 2086 (1987). (Original)
K. Valentino, R. Newcomb, T. Gadbois, T. Singh, S. Bowersox, S. Binter, A. Justice, D. Yamashiro, B.B. Hoffman,
R. Ciaranello, G. Miljanich, and J. Ramachandran, Proc. Natl. Acad. Sci. USA, 90, 7894 (1993). (Pharmacol.)
J.A. Fox, Pflügers Arch., 429, 873 (1995). (Pharmacol.)
Cas : 107452-89-1
