H-Ala-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys-Gly-Gly-Gly-Ser-C6-Lys-Lys(NOTA)-NH2 (trifluoroacetate salt)
(Reduced Cys-H)
Size : 1
P1(RMB) : 2380
MW : 2023.36
One letter sequence : ACGEMGWVRCGGGS-C6-K-K(NOTA)-NH2
Molecular Formula : C84H139N27O25S3
Description : Metal chelating peptide Pep-1L-NOTA targets tumor-restricted receptor, IL13RA2, found to be present in some aggressive malignancies, specifically gliomas and malignant melanoma. Recent work has demonstrated that the copper-bound peptide selectively binds hIL13RA2-expressing tumors and validates its use in peptide-based PET imaging for cancer diagnostics.
Literature Reference : Sai, Kiran Kumar Solingapuram, et al. "Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker." Oncotarget 5 (2017).
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