Rapid PD-L1 detection in tumors with PET using a highly specific peptide.

Chatterjee, Samit, et al. Biochemical and Biophysical Research Communications 483.1 (2017): 258-263.

WL12 peptide selectively binds to programmed death ligand 1 (PD-L1), an immune checkpoint protein that is overexpressed in many cancer cell lines. Tumor PD-L1 expression contributes to immune system depression and is indicative of a tumor’s response to PD-L1 and PD-1.

“PD-L1 binding peptide, WL12, was custom synthesized by Chinese Peptide Company (Sunnyvale, CA) with >95% purity.”